Pazienza was forced to relinquish the title due to a serious car accident in which his neck was broken. He was scheduled for a Jan 10 title defense against Pat Lawlor in Atlantic City but it was called off. Doctors informed him he might never walk again and would certainly never fight again. Pazienza had to wear a medical device called a Halo, a circular metal brace screwed into the skull in four spots and propped up with four metal rods. He had the Halo screwed to his skull for three months, during which time he maintained a workout regimen against doctors’ orders. He returned to the ring thirteen months after the accident and defeated future WBC World Jr. Middleweight Champion Luis Santana by a 10-round decision.
After the Santana fight, Pazienza went on to defeat Brett Lally by a 6th-round TKO, and then, in another TKO, former World Champion Lloyd Honeyghan in the 10th round. Pazienza went on to win the vacant IBO Middleweight World title in 1993 with an 11th-round KO over Dan Sherry. Pazienza then went on to beat Roberto Durán twice, both via unanimous decision, with the IBC Super Middleweight title on the line both times. In 1996, Pazienza inflicted then-prospect Dana Rosenblatt’s only loss (a knockout in four rounds) to win the vacant WBU Super Middleweight World Championship.
In early 2001, Pazienza legally changed his last name to Paz. In 2004, Paz fought in his last fight, defeating Tocker Pudwill via a 10-round unanimous decision. His record stands at 50–10, with 30 wins by knockout and five World Titles (the IBF Lightweight Championship, WBA Jr. Middleweight Championship, IBO Super Middleweight Championship, IBC Super Middleweight Championship, and the WBU Super Middleweight Championship). He also won the USBA title.